Amfenac sodium salt monohydrate
Fenazox
CAS: 61618-27-7
Molecular Formula: C15H12NNaO3.H2O
Amfenac sodium salt monohydrate - Names and Identifiers
Amfenac sodium salt monohydrate - Physico-chemical Properties
| Molecular Formula | C15H12NNaO3.H2O |
| Molar Mass | 295.27 |
| Melting Point | 242-244°C |
| Solubility | Methanol (Slightly), Water (Slightly) |
| Appearance | Solid |
| Color | Yellow |
| Storage Condition | Keep in dark place,Inert atmosphere,2-8°C |
| In vitro study | Amfenac is a potent inhibitor of COX-1 and COX-2 with IC50 of 0.25 and 0.15 μM, respectively. |
| In vivo study | Amfenac acts in vivo with antipyretic and analgesic properties. Amfenac (4 mg/kg) inhibited 33% of acute (Evans blue-carrageenan pleural effusion) and 28% of chronic (adjuvant-induced inflammation), respectively, the potency of its action is 16.4 and 22.8 times that of butaisson, respectively. Amfenac has 43 times the analgesic activity of acetylsalicylic acid in Randall-Selitto assays and acts on dogs with acetylcholine-induced abdominal contractions in mice and bradykinin-induced pain responses, its potency was 156 and 56.3 times stronger than that of butaisson, respectively. Amfenac, when administered topically to the gastric mucosa of cats or orally to rats and dogs, produced less gastric irritation than acetylsalicylic acid. When subchronically administered orally to rats, the therapeutic rate of Amfenac was twice that of bethasone. |
Supplier List
Multiple SpecificationsSpot supply
Product Name: Fenazox Visit Supplier Webpage Request for quotationCAS: 61618-27-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
Multiple SpecificationsSpot supply
Product Name: Fenazox Visit Supplier Webpage Request for quotationCAS: 61618-27-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
View History